Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC011
Test administered by neuromedic@manusdevices.net
Test date and time 2022-11-03 16:39
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment old patient tbl Madopar 250mg 1\2,1\4,1\4,1\4

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 34 individuals with a value less than 0.66 were subsequently diagnosed with PD. That is, 80.95% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.66 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 17, 'TN': 12, 'TP': 25, 'FP': 18}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 36, 'TN': 27, 'TP': 6, 'FP': 3}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 20, 'TN': 10, 'TP': 22, 'FP': 20}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 9, 'TN': 7, 'TP': 33, 'FP': 23}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 11.536
timePerCircleCoV 0.149311
timePerCircleSlope -0.00479133
meanError 1.61849
tremorFreq 7.22656
tremorRelPower 33.2149
tremorGyroAmpMean 0.0171077
tremorGyroAmpSlope -0.00446739
tremorGyroAmpCoV 0.379362
tremorCoordAmpMean 0.0334637
tremorCoordAmpSlope -0.00173887
tremorCoordAmpCoV 0.272607
tremorAccAmpMean 0.0219693
tremorAccAmpSlope -0.00335446
tremorAccAmpCoV 0.379904
tremorPcRelVar 0.642692
tremorPcX -0.193608
tremorPcY 0.981079

Circle Segment 1

Duration 12.12 s, Accuracy Estimate 1.779 (lower is better)

Circle Segment 2

Duration 10.24 s, Accuracy Estimate 1.447 (lower is better)

Circle Segment 3

Duration 9.88 s, Accuracy Estimate 1.669 (lower is better)

Circle Segment 4

Duration 13.12 s, Accuracy Estimate 1.648 (lower is better)

Circle Segment 5

Duration 10.76 s, Accuracy Estimate 1.48 (lower is better)

Circle Segment 6

Duration 14.64 s, Accuracy Estimate 1.755 (lower is better)

Circle Segment 7

Duration 12.8 s, Accuracy Estimate 1.294 (lower is better)

Circle Segment 8

Duration 11.08 s, Accuracy Estimate 1.671 (lower is better)

Circle Segment 9

Duration 11.88 s, Accuracy Estimate 1.469 (lower is better)

Circle Segment 10

Duration 8.84 s, Accuracy Estimate 1.971 (lower is better)

Spiral

numSpirals 8
timePerSpiralMean 35.065
timePerSpiralCoV 0.0979858
timePerSpiralSlope -0.0257888
meanError 2.37546
tremorFreq 5.85938
tremorRelPower 23.32
tremorGyroAmpMean 0.0180093
tremorGyroAmpSlope -0.000130309
tremorGyroAmpCoV 0.37886
tremorCoordAmpMean 0.0368279
tremorCoordAmpSlope 0.000685876
tremorCoordAmpCoV 0.284996
tremorAccAmpMean 0.050268
tremorAccAmpSlope 7.1785e-05
tremorAccAmpCoV 0.154196
tremorPcRelVar 0.672801
tremorPcX -0.458422
tremorPcY -0.888735

Spiral Segment 1

Duration 38.52 s, Accuracy Estimate 2.142 (lower is better)

Spiral Segment 2

Duration 37.96 s, Accuracy Estimate 2.07 (lower is better)

Spiral Segment 3

Duration 33.88 s, Accuracy Estimate 1.896 (lower is better)

Spiral Segment 4

Duration 36.04 s, Accuracy Estimate 3.103 (lower is better)

Spiral Segment 5

Duration 38.48 s, Accuracy Estimate 2.899 (lower is better)

Spiral Segment 6

Duration 29.16 s, Accuracy Estimate 1.976 (lower is better)

Spiral Segment 7

Duration 35.08 s, Accuracy Estimate 2.48 (lower is better)

Spiral Segment 8

Duration 31.4 s, Accuracy Estimate 2.437 (lower is better)

Elel

eDurationMean 0.585139
eDurationStd 0.105312
eDurationStdnorm 0.179978
eDurationMedian 0.5625
eDurationQuartdelta 0.125
eDurationQuartdeltanorm 0.222222
eDurationKurt 2.62937
eDurationTrenddiff -0.0625
eDurationTrendratio 0.895397
eWidthMean 2.8405
eWidthStd 0.988281
eWidthStdnorm 0.347925
eWidthMedian 2.574
eWidthQuartdelta 0.8775
eWidthQuartdeltanorm 0.340909
eWidthKurt 2.92133
eWidthTrenddiff -0.117
eWidthTrendratio 0.954545
eHeightMean 6.06775
eHeightStd 1.41043
eHeightStdnorm 0.232448
eHeightMedian 6.084
eHeightQuartdelta 1.989
eHeightQuartdeltanorm 0.326923
eHeightKurt 3.04471
eHeightTrenddiff 0.1755
eHeightTrendratio 1.02885
eAspectMean 0.467437
eAspectStd 0.115316
eAspectStdnorm 0.246698
eAspectMedian 0.466667
eAspectQuartdelta 0.167955
eAspectQuartdeltanorm 0.359903
eAspectKurt 2.52365
eAspectTrenddiff -0.0366823
eAspectTrendratio 0.923297
eSlantMean -0.127275
eSlantStd 0.214075
eSlantStdnorm -1.68199
eSlantMedian -0.0938416
eSlantQuartdelta 0.265606
eSlantQuartdeltanorm -2.83036
eSlantKurt 2.61367
eSlantTrenddiff 0.15919
eRtopMean 0.780427
eRtopStd 0.142835
eRtopStdnorm 0.183022
eRtopMedian 0.828431
eRtopQuartdelta 0.200234
eRtopQuartdeltanorm 0.241702
eRtopKurt 2.32957
eRtopTrenddiff -0.0236695
eRbotMean 1.09386
eRbotStd 0.467878
eRbotStdnorm 0.427729
eRbotMedian 1.07125
eRbotQuartdelta 0.547746
eRbotQuartdeltanorm 0.511315
eRbotKurt 6.39374
eRbotTrenddiff -0.0950658
eRrightMean 0.885356
eRrightStd 0.0936263
eRrightStdnorm 0.10575
eRrightMedian 0.902381
eRrightQuartdelta 0.124119
eRrightQuartdeltanorm 0.137546
eRrightKurt 4.42995
eRrightTrenddiff -0.0448445
eRleftMean 0.463705
eRleftStd 0.135292
eRleftStdnorm 0.291763
eRleftMedian 0.480031
eRleftQuartdelta 0.158367
eRleftQuartdeltanorm 0.329909
eRleftKurt 2.77279
eRleftTrenddiff 0.0211598
lDurationMean 0.76
lDurationStd 0.0971277
lDurationStdnorm 0.1278
lDurationMedian 0.7525
lDurationQuartdelta 0.125
lDurationQuartdeltanorm 0.166113
lDurationKurt 3.48854
lDurationTrenddiff 0.025
lDurationTrendratio 1.03378
lWidthMean 4.61226
lWidthStd 1.0777
lWidthStdnorm 0.23366
lWidthMedian 4.446
lWidthQuartdelta 1.521
lWidthQuartdeltanorm 0.342105
lWidthKurt 2.4165
lWidthTrenddiff 1.42109e-14
lWidthTrendratio 1
lHeightMean 13.6674
lHeightStd 2.20686
lHeightStdnorm 0.161468
lHeightMedian 13.6305
lHeightQuartdelta 3.51
lHeightQuartdeltanorm 0.257511
lHeightKurt 2.31763
lHeightTrenddiff 1.521
lHeightTrendratio 1.1215
lAspectMean 0.338918
lAspectStd 0.070486
lAspectStdnorm 0.207974
lAspectMedian 0.331407
lAspectQuartdelta 0.0917391
lAspectQuartdeltanorm 0.276817
lAspectKurt 3.44819
lAspectTrenddiff -0.0222336
lAspectTrendratio 0.933884
lSlantMean 0.0124008
lSlantStd 0.127413
lSlantStdnorm 10.2745
lSlantMedian 0.0247995
lSlantQuartdelta 0.158618
lSlantQuartdeltanorm 6.39604
lSlantKurt 3.82938
lSlantTrenddiff -0.00482282
lRtopMean 0.749086
lRtopStd 0.123546
lRtopStdnorm 0.164929
lRtopMedian 0.758813
lRtopQuartdelta 0.189931
lRtopQuartdeltanorm 0.250301
lRtopKurt 3.02915
lRtopTrenddiff 0.0571429
lRbotMean 0.747701
lRbotStd 0.32683
lRbotStdnorm 0.437113
lRbotMedian 0.679814
lRbotQuartdelta 0.303571
lRbotQuartdeltanorm 0.446551
lRbotKurt 4.79971
lRbotTrenddiff -0.0537037
lRrightMean 0.843873
lRrightStd 0.0901303
lRrightStdnorm 0.106806
lRrightMedian 0.864022
lRrightQuartdelta 0.134421
lRrightQuartdeltanorm 0.155576
lRrightKurt 3.38556
lRrightTrenddiff 0.048365
lRleftMean 0.399602
lRleftStd 0.144776
lRleftStdnorm 0.362301
lRleftMedian 0.380597
lRleftQuartdelta 0.255101
lRleftQuartdeltanorm 0.670265
lRleftKurt 1.79662
lRleftTrenddiff 0.0132501

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

Elel Segment 13

Elel Segment 14

Elel Segment 15

FITTS Short Modified

meanTouchScore 0.998364
sumTouchScores 12.9787
meanMovementTime 1.32208
numTouches 13
undershootPercentage 0
overshootPercentage 0

FITTS Long Modified

meanTouchScore 0.981604
sumTouchScores 14.7241
meanMovementTime 1.23679
numTouches 15
undershootPercentage 0
overshootPercentage 0

ZigZag

numZigzags 5
timePerZigzagMean 28.296
timePerZigzagCoV 0.114104
timePerZigzagSlope -0.0268589
meanError 2.19281
tremorFreq 7.12891
tremorRelPower 36.0941
tremorGyroAmpMean 0.0175764
tremorGyroAmpSlope -0.00586481
tremorGyroAmpCoV 0.485328
tremorCoordAmpMean 0.0410406
tremorCoordAmpSlope -0.0018291
tremorCoordAmpCoV 0.320116
tremorAccAmpMean 0.0275522
tremorAccAmpSlope -0.00263991
tremorAccAmpCoV 0.378164
tremorPcRelVar 0.756169
tremorPcX -0.317422
tremorPcY -0.948284

ZigZag Segment 1

Duration 33.52 s, Accuracy Estimate 2.863 (lower is better)

ZigZag Segment 2

Duration 25.16 s, Accuracy Estimate 2.398 (lower is better)

ZigZag Segment 3

Duration 26.2 s, Accuracy Estimate 1.803 (lower is better)

ZigZag Segment 4

Duration 28.6 s, Accuracy Estimate 1.85 (lower is better)

ZigZag Segment 5

Duration 28.0 s, Accuracy Estimate 2.05 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 22.432
timePerZigzagCoV 0.118567
timePerZigzagSlope -0.0526034
zigzagHeightMean 88.1836
zigzagHeightCoV 0.0698252
zigzagHeightSlope 0.0231772
meanError 0.0327284
tremorFreq 6.05469
tremorRelPower 29.993
tremorGyroAmpMean 0.0488386
tremorGyroAmpSlope -0.00808562
tremorGyroAmpCoV 0.42258
tremorCoordAmpMean 0.0704644
tremorCoordAmpSlope -0.00110035
tremorCoordAmpCoV 0.297106
tremorAccAmpMean 0.0556079
tremorAccAmpSlope -0.000967769
tremorAccAmpCoV 0.396712
tremorPcRelVar 0.811505
tremorPcX -0.329297
tremorPcY -0.944226

ZigZag Offset Segment 1

Duration 27.08 s, Accuracy Estimate 0.027 (lower is better)

ZigZag Offset Segment 2

Duration 21.2 s, Accuracy Estimate 0.043 (lower is better)

ZigZag Offset Segment 3

Duration 21.0 s, Accuracy Estimate 0.026 (lower is better)

ZigZag Offset Segment 4

Duration 22.2 s, Accuracy Estimate 0.026 (lower is better)

ZigZag Offset Segment 5

Duration 20.68 s, Accuracy Estimate 0.042 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.75}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.66}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.6854304479669431}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9029432790066354}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.7740070014563843}